Waa dihydrocoumarin sun ah

DIHYDROCOUMARIN, udgoon, oo loo isticmaalo cuntada, waxaa sidoo kale loo isticmaalay in coumarin lagu beddelo, loo isticmaalo sida dhadhanka qurxinta; Isku qas kareem, qumbaha, dhadhanka qorfe; Waxaa sidoo kale loo isticmaalaa sidii dhadhanka tubaakada.

Waa dihydrocoumarin sun ah

DIHYDROSOUMARIN MA AHAAN. DIHYDROSOUMARIN waa wax soo saar dabiici ah oo laga helo rland rhinoess-ka jaalaha ah ee vantilla. Waxaa lagu diyaariyay hawo-mareenka coumarin ee ku saabsan jiritaanka caleenta nickel ee 160-200 ℃ iyo cadaadis. Waxaa sidoo kale loo istcimaali karaa sida shey ceyriin ah, hydrolyzed xalka alkaline ee aquline si loo soo saaro o-hydroxyphylproponic acid, fuuq-baxa, fuuq-saar.

Xaaladda kaydinta

Xidh xidhan oo mugdi ah, oo lagu keydiyo meel qabow oo qalalan, booska fooska ee foosto waa mid yar sida ugu macquulsan ee suurtogalka ah ee ku habboon rukhsaynta amniga, waxaana ka buuxsamay ilaalinta nitrogen. Ku keydi bakhaar qabow, hawo hawo leh. Ka fogow dabka, biyaha. Waa in si gaar ah loogu keydiyaa si gaar ah oo ka socda oxidizer, ha isku qasin kaydinta. Ku qalabeysan noocyada u dhigma iyo tirada qalabka dabka.

Barashada vitro

Vitro Enzyratic Assay, DIHYDROSOUMARIONAIND INTERACT-ku-tiirsanaanta ku tiirsan-xannaaneynta SIR1 (IC50) ee 208μm). Hoos udhaca waxqabadka SIT1 ayaa la arkay xitaa wax qaddarka Micromlase (85 ± ee 58 iyo 73 ± 13.7% Waxqabadka 1.6μm iyo 8μm, siday u kala horreeyaan). Microtubuhule Sirt2 Deapeylase ayaa sidoo kale xannibay qaab isku mid ah oo lagu qiyaasi karo (IC50 ee 295μm).

Ka dib 24 saac oo soo-gaadhis ah, DIHYDROSOUMarin (1-5mm) Kordhinta cytotomicity-ka khadadka unugyada TK6 ee hab ku tiirsan. DIHYDROSOUMAR (1-5mm) ayaa ku kordhay Apoptosis ee khadadka unugyada TK6 ee ku tiirsan qiyaasta qiyaasta 6-saac waqti. Qiyaasta 5mm ee DIHYDROSOUMARE waxay ku kordheen Apoboptosis waqti 6-saac waqti ah khadka tooska ah ee TK6. Muddo 24-saac ah ka dib, DIHYDROCOUMARIN (1-5mm) Kordhi P53 LYSIne 373 iyo 382 Achetylation oo ku jirta hab ku tiirsan qadka TK6.