Miyuu dihydrocoumarin sun ah

Dihydrocoumarin, udgoon, loo isticmaalo cuntada, sidoo kale loo isticmaalo beddelka coumarin, loo isticmaalo dhadhan qurxinta; Isku qas kareem, qumbaha, dhadhan qorfe; Waxa kale oo loo isticmaalaa dhadhanka tubaakada.

Miyuu dihydrocoumarin sun ah

Dihydrocoumarin ma aha sun. Dihydrocoumarin waa badeecad dabiici ah oo laga helo wiyisha vaniljka jaalaha ah. Waxaa lagu diyaariyaa hydrogenation of coumarin iyadoo joogitaanka nikkel kiciya at 160-200 ℃ iyo cadaadis. Waxa kale oo loo isticmaali karaa sida alaabta ceeriin, hydrolyzed in xal aqueous alkaline si ay u soo saaraan o-hydroxyphenylpropionic acid, fuuqbax, xiran-loop helay.

Xaaladda kaydinta

Xiran iyo mugdi, lagu kaydiyaa meel qabow oo qallalan, booska foosto waa sida ugu yar ee suurtogalka ah iyadoo la raacayo oggolaanshaha badbaadada, waxaana ka buuxa ilaalinta nitrogen. Ku kaydi bakhaar qabow oo hawo leh. Dabka ka fogow, biyo. Waa in si gooni ah loo kaydiyaa oksidizer, ha isku darin kaydinta. Lagu qalabeeyay noocyada u dhigma iyo tirada qalabka dabka.

Barashada in vitro

In vitro enzymatic assay, dihydrocoumarin waxay keentay xannibaadda ku-tiirsanaanta ku-tiirsanaanta SIRT1 (IC50 ee 208μM). Hoos u dhigista SIRT1 dhaqdhaqaaqa deacetylase ayaa lagu arkay xitaa qiyaasaha micromolar (85± 5.8 iyo 73± 13.7% dhaqdhaqaaqa 1.6μM iyo 8μM, siday u kala horreeyaan). Microtubule SIRT2 deacetylase sidoo kale waxaa lagu hakiyay qaab isku mid ah oo ku tiirsan qiyaasta (IC50 ee 295μM).

Ka dib 24 saacadood oo soo-gaadhis ah, dihydrocoumarin (1-5mM) waxay kordhisay cytotoxicity ee khadadka unugyada TK6 iyadoo loo eegayo qiyaasta qiyaasta. Dihydrocoumarin (1-5mM) waxay kordhisay apoptosis ee khadadka unugyada TK6 qaab ku-tiirsanaan ah oo ah wakhti 6-saac ah. Qiyaasta 5mM ee dihydrocoumarin waxay kordhisay apoptosis waqti 6-saac ah oo khadka unugyada TK6 ah. Muddo 24-saac ah ka dib, dihydrocoumarin (1-5mM) waxay kordhisay p53 lysine 373 iyo 382 acetylation qaab ku-tiirsanaan ah oo ku jira khadka unugyada TK6.